Fast growing goitre as the first clinical manifestation of systemic amyloidosis.

Introduction Systemic amyloidosis is often associated with microscopic deposits in the thyroid gland (Kennedy, Thompson and Buchanan, 1974). Far less frequently the amyloid deposits are large enough to become palpable. When this occurs, there is usually clinical or biochemical evidence of hepatic or renal involvement (Kennedy et al., 1974). A case is reported in which the initial manifestation of amyloidosis was the presence of a fast growing goitre without other clinical or biochemical abnormalities.